NSAIDS – NON-STEROIDAL ANTI-INFLAMMATORY DRUGS
They are symptomatic anti-inflammatory, anti febrile (fever) and analgesic (pain reducing) medications. Symptomatic means that they do not affect the course of the disease, but serve to controls symptoms. They act mainly by blocking an enzyme, which is important for the formation of substances that can cause inflammation. On the other hand, these substances also have a physiological role in the body that includes stomach protection and regulation of blood flow in the kidney. These physiological effects explain most of the side effects of NSAIDs. Know more....  

Henoch-Schoenlein Purpura (HSP) is a condition in which small blood vessels get inflamed. This inflammation is called vasculitis and usually affects the small blood vessels in the skin, bowel and kidneys. The inflamed blood vessels may bleed into the skin causing a deeply red or purple rash called purpura. They can also bleed in the intestine or kidneys causing blood-stained stools or urine (hematuria). HSP was named after Drs Henoch and Schoenlein who both described it independently more than one hundred years ago. Know more....  

Juvenile dermatomyositis (JDM) belongs to a group of diseases called autoimmune diseases. In autoimmune diseases an abnormal reaction of the immune system causes an inflammation in body tissues when no infection is present. In dermatomyositis, the inflammation is in very small blood vessels in muscle (myositis) and skin (dermatitis). This leads to characteristic symptoms, such as muscle weakness, or pain, mainly in the muscles surrounding the hip and shoulder girdle, and skin eruptions in the face, above the eyelids, on the knuckles, knees and elbows. The disease can be present in children and in adults. If the symptoms of dermatomyositis present before the age of 16 years, the disease is addressed as the juvenile form. Know more....  

Juvenile idiopathic arthritis (JIA) is a chronic disease characterized by persistent joint inflammation; the typical signs of joint inflammation are pain, swelling and limitation of movement. “Idiopathic” means that we don’t know the cause of the disease and “juvenile”, in this case, means that symptoms appear before 16 years of age. Know more....  

The juvenile spondyloarthropathies constitute are a group of chronic inflammatory diseases of the joints (arthritis) and tendon attachments to certain bones (enthesitis) affecting, predominantly, the lower limbs and, in some cases, the pelvic and spinal joints (sacroliitis - buttock pain and spondolytis - lower back pain).

In some cases, the onset of symptoms is triggered by enteric (gastro-intestinal) or urogenital bacterial infections (reactive arthritis). Juvenile spondyloarthropathies are significantly more common in people carrying HLA-B27, a genetic marker, which predispose individuals to this disease, although why this is the case is not fully understood, as yet.

The prevalence of some clinical features at onset and severity throughout the course of the disease, differ in the childhood form to those of adults, but may still resemble adult onset spondyloarthropathies.

Patients with juvenile idiopathic arthritis, classified into the enthesitis related arthritis group (see JIA information), are included in the group of juvenile spondyloarthropathies Know more....  

This disease was described in 1967 by a Japanese paediatrician called Tomisaku Kawasaki. He recognized a group of children with fever, skin rash, conjunctivitis, enanthem (redness of the throat and oral mucosa), swelling of the hands and feet and enlarged lymph nodes (filters that kill bacteria and viruses) in the neck, initially called mucocutaneous lymph node syndrome. A few years later, heart complications, like aneurysms of the coronary arteries (large dilatation of blood vessels) were reported. Know more....  

1) Fibromyalgia Syndrome Synonyms
2) Localized Idiopathic Musculoskeletal Pain Syndrome Synonyms
3) Erythromelalgia
4) Growing Pains
5) Benign Hypermobility Syndrome
6) Transient Synovitis
7) Patellofemoral Pain - Knee pain
8) Slipped Capital Femoral Epiphysis
9) Osteochondroses (Synonyms Osteonechroses, Avascular necroses)
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Vasculitis is an inflammation of blood vessels. Vasculitides cover a wide group of diseases. Primary vasculitis means that the blood vessels are the main part of the body effected by the disease. The name and classification of vasculitis depends upon the size and type of blood vessels involved. Know more....  

Recent progresses in research have clearly shown that some rare fever diseases are caused by a genetic anomaly. In many of them, other members of the family can also suffer from recurrent fevers. Know more....  

Rheumatic fever has been defined as a disease triggered by infection caused by streptococcus. The disease may cause permanent damage to the heart, and presents itself by transient arthritis, carditis, or a movement disorder called chorea, in addition to skin rashes or skin nodules. Know more....  

Scleroderma is a Greek word that can be translated as “hard skin”. In this disease, the skin becomes shiny and hard. There is a wide variety of diseases in which skin hardening is the most prominent feature and there are two different types of Scleroderma, localised and systemic scleroderma.

In localised scleroderma the disease is limited to skin and the tissues located under the affected skin. It can be in patches (morphea), or occur as a tight band (linear scleroderma).

In systemic scleroderma (or systemic sclerosis) the process is wide-spread and involves not only the skin, but also the internal organs of the body. This can lead to different symptoms, including heartburn, difficulty in breathing, and high blood pressure. Know more....  

Systemic lupus erythematosus (SLE) is a chronic autoimmune disease (meaning that the immune system attacks the body instead of viruses and bacteria). It can affect various organs of the body, especially the skin, joints, blood and kidneys. SLE is a chronic disease, which means that it can last for a long time.

The name systemic lupus erythematosus dates back to the early 20th century. Systemic means affecting many organs of the body. The word lupus is derived from the Latin word for wolf, and refers to the characteristic butterfly like rash on the face, which reminded doctors of the white markings present on a wolf’s face. Erythematosus in Greek means red, and refers to the redness of the skin rash. Know more....